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KMID : 0357919750090010021
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Korean Journal of Pathology
1975 Volume.9 No. 1 p.21 ~ p.28
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An Experimental Study on Metaplasia in Traeheo-bronchial Epithelium of Rats, Exposed to Nitrogen Dioxide
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함의광(咸毅壙)/Eui Keun Ham
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Abstract
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Bronchial epithelial metaplasia of the rats was experimentally studied by mean of
inhalation of Nitrogen Dioxide (1,000ppm, 500ppm and 100ppm in concentration).
Used animals were healthy adult rats weighing about 250gm and having no
pulmonasy diseases. NO2 gas was administered according to the exposure
chamber and 10 sections were taken from the definite sites of the trachea and main
bronchi of lungs.
The following results and conclusions were made.
1. In the group of control(0 ppm NO2) was net observed any typical
squamous metaplasia of bronchial epithelium in the course of time.
2. In the group which was exposed to the NO2 gas, the incidence of
epithelial metaplasia of trachea and bronchi was approximately 83 per cent. Male rat
(93% positive) showed definite high positivity compared to the female rat (78%
positivity).
3. In the groups which was exposed for long time (-average 74hrs-90% positive),
metaplastic tendency was apparently increased compared to that of short term
exposure groups(-average 6 and 7hrs-78% positive). But invasiveness of metaplasia
was relatively high and especially conspicuous in the groups of high
NO2 concentration (1, 000ppm and 500ppm).
4. Observation on distribution of metaplasia indicated that site prepondence was
trachea, carina and right upper lobe bronchus in orders, which were proximal parts
of tracheobronchial tree. But on range of metaplasia, failed to indicate any
specificity.
5. In the group which was exposed to NO2 gas epithelial finidings to be
consistent with atypical metaplasia or carcinoma in situ were not observed.
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KEYWORD
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